Polak S, Wisniowska B, Brandys J. Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs cardiotoxic properties. Journal of Applied Toxicology, 2009;29(3):183-206.

Wisniowska B, Polak S. hERG in vitro interchange factors - development and verification. Toxicology Mechanisms and Methods, 2009;19(4):278-284.

Wisniowska B, Mendyk A, Polak M, Szlek J, Polak S. RandomForest based assessment of the hERG channel inhibition potential for the early drug cardiotoxicity testing. Bio-Algorithms and Med-Systems, 2010;6(12):131-136.

Polak S, Wisniowska B, Ahamadi M, Mendyk A. Prediction of the hERG potassium channel inhibition potential with use of Artificial Neural Networks. Applied Soft Computing, 2011;11(2):2611-2617.

Polak S, Wisniowska B, Fijorek K, Glinka A, Polak M, Mendyk A. The open-access dataset for in silico cardiotoxicity prediction system. Bioinformation, 2011;6(6):244-245.

Wisniowska B., Ahamadi M., Mendyk A., Polak S. Bayesian nets based model for the hERG channel inhibition prediction, under review.

Fijorek K, Fijorek D. The effectiveness of best subset variable selection in Firth logistic regression. Applied Informatics Methods, accepted for publication.

Fijorek K, Fijorek D, Wisniowska B, Polak S. BDTcomparator: a program for comparing binary classifiers. Bioinformatics, 2011;27(24):3439-3440.

Polak S, Fijorek K, Glinka A, Wisniowska B, Mendyk A. Virtual population generator for human cardiomyocytes parameters. In silico drug cardiotoxicity assessment. Toxicology Mechanisms and Methods, 2012;22(1):31-40.

Polak S, Wisniowska B, Glinka A, Fijorek K, Mendyk A. Slow delayed rectifying potassium current (IKs) – analysis of the in vitro inhibition data and predictive model development. Journal of Applied Toxicology, accepted for publication.

Barbara Wisniowska, Sebastian Polak, Jerzy Brandys. Extrapolating factors for different in vitro hERG systems. Central European Congress of Life Science EUROBIOTECH 2008, Kraków 17-19.10.2008; Acta Biochimica Polonica 2008, vol. 55 suppl. 4

Sebastian Polak, Barbara Wisniowska, Jerzy Brandys. Modelling and simulation in the drug discovery, research and development. Toxicity prediction. 5th German-Polish Symposium “New Challenges for Pharmaceutical Sciences”, Poznan 15-16.05.2009

Barbara Wisniowska, Sebastian Polak, Jerzy Brandys. Bayesian classification methods for proarrhythmic liability prediction. 5th German-Polish Symposium “New Challenges for Pharmaceutical Sciences”, Poznan 15-16.05.2009

Sebastian Polak, Barbara Wisniowska, Jerzy Brandys. Decision trees algorithms for the in silico prediction of hERG potassium channels inhibition (in polish). Polish Society of Toxicology Workshop “New trends in toxicology”, Lodz 1-2.06.2009

Barbara Wisniowska, Sebastian Polak. Cardiotoxicity prediction algorithms. 1st International Workshop Computational Pharmacy, Krakow 19.06.2009

Sebastian Polak. Modelling and simulations in modern pharmacy – bridging regulatory bodies, academia and industry. 3rd BBBB-Bosphorus International Conference on Pharmaceutical Sciences, Antalya, Turkey 26-28.10.2009; European Journal of Pharmaceutical Sciences 2009, vol. 38, Issue 1, Supplement

Sebastian Polak, Barbara Wisniowska, Malidi Ahamadi, Aleksander Mendyk. Prediction of the hERG potassium channel inhibition potential with use of the artificial neural networks. 14th Online World Conference on Soft Computing in Industrial Applications (WSC14), 17-29.11.2009

Barbara Wisniowska, Aleksander Mendyk, Milosz Polak, Jakub Szlek, Sebastian Polak. RandomForest based assessment of the hERG channel inhibition potential for the early drug cardiotoxicity testing (polish/english). MCSB 2010, Krakow 21-22.05.2010

Sebastian Polak, Barbara Wisniowska, Malidi Ahamadi, Aleksander Mendyk. Prediction of the hERG potassium channel inhibition potential with use of the artificial neural networks. Soft Computing in Industrial Applications. Algorithms, Integration and Success Stories. In Advances in Intelligent and Soft Computing vol. 75 Eds. Gao X-Z, Gaspar-Cunha A., Koeppen M., Schaefer G., Wang J. Springer, Berlin 2010.

Sebastian Polak. Combining systems biology and pharmacokinetics - drug cardiotoxicity assessment. 2011 CellML Workshop. Auckland, 11-12.04.2011 (on line presentation).

Sebastian Polak, Barbara Wisniowska, Kamil Fijorek, Anna Glinka, Miłosz Polak, Aleksander Mendyk. ToxComp - in silico platform for the cardiotoxicity assessment – in vitro-in vivo extrapolation. Applied Pharmaceutical Toxicology Workshop; May 18 - 20 2011; San Francisco, CA, USA

Sebastian Polak, Aleksander Mendyk. Computational toxicology. In silico assessment of the hERG channel inhibition potential for the early drug cardiotoxicity testing. Chemaxon 2011 European UGM, Training day and Markush Forum, May 16-19, Budapest, Hungary

Mini-symposium Computational toxicology and pharmacology - in silico drug activity and safety assessment (Saturday, July 2, 11:00) during the 8-th European Conference on Mathematical and Theoretical Biology and Annual Meeting of The Society for Mathematical Biology; June 28^th - July 2^nd 2011, Krakow, Poland.

Mini-symposium Computational toxicology - in silico drug safety assessment during the 3rd Annual Predictive Toxicology; 14-16 September 2011; Berlin, Germany.

Polak S. Optimization of the use of information for in vitro and in silico to predict in vivo Computational toxicology - in silico drug safety assessment during the 3rd Annual Predictive Toxicology; September 14^th - 16^th 2011; Berlin, Germany.

Half day long workshop Tox IVIVE - inter-individual variability matters! September 14^th - 16^th 2011; Berlin, Germany. All materials are available for download here.

Polak S, Glinka A, Wisniowska B, Mendyk A. Influence on the physiological parameters on the ADP90 value simulated by human venrticular tissue model. Eurotox 2011, August 28^th - 31^st; Paris, France.

On-line workshop 3rd International Workshop - Computational Pharmacy; September 22^nd, 2011; Krakow, Poland (Internet!).

The 16th Online World Conference on Soft Computing in Industrial Applications (WSC16); December 5^th - 16^th, 2011 INTERNET! Team achievements were presented during the special session - Special Session on Soft Computing Methods in Pharmaceutical and Medical Sciences.

Polak S, Mishra H. Combining In Vitro-In Vivo Extrapolation (IVIVE) and Physiologically-Based Pharmacokinetics (PBPK) with Drug Related Risk Assessment - Cardiotoxicity prediction. 7^th Annual International Conference on Predictive Human Toxicity and ADME/Tox Studies; January 26^th - 27^th, 2012; Brussels, Belgium.

-------

We will be presenting

4^th Workshop on using Computational Methods in Pharmaceutical Sciences is a one day long training which will take place on 8^th of September, 2012 in Krakow, Poland. Workshop will be a part of the Computers in Cardiology Conference - CinC 2012. The main goal of the Workshop is to provide in depth, practical information about design, development, validation and implementation of the computational methods used in the pharmaceutical sciences with focus put on the early drugs cardiotoxicity prediction.

-------

We were cited

Hishigaki H, Kuhara S. hERGAPDbase: a database documenting hERG channel inhibitory potentials and APD-prolongation activities of chemical compounds Database: The Journal of Biological Databases and Curation. 2011; published online May 17^th.

Migliorini C, Lave T, Parrott NJ, Reddy M, Grimm HP, Penland RC, Soubret A, Helmlinger G, Georgieva A, Zuideveld KP. Systems Toxicology Modeling for Prediction in Humans. 2011; in Sahu SC et al. General, Applied and System Toxicology. Chichester, West Sussex, U.K: John Wiley & Sons.

Tan Y, Chen Y, You Q, Sun H, Li M. Predicting the potency of hERG K⁺ channel inhibition by combining 3D-QSAR pharmacophore and 2D-QSAR models Journal of Molecular Modeling. 2011; Published online June 10^th.

Su Z, Gintant G. Preclinical Drug Safety and Cardiac Ion Channel Screening Heart Rate and Rhythm. 2011;Part 7:627-638.

Church MK. Safety and efficacy of bilastine: a new H1-antihistamine for the treatment of allergic rhinoconjunctivitis and urticaria. Expert Opinion on Drug Safety. 2011;10(5):779-793.

Schuster AM, Glassmeier G, Bauer CK. Strong activation of erg1 K+ channel isoforms by NS1643 (1,3-bis-(2-hydroxy-5-trifluoromethylphenyl)-urea) in HEK-293 and CHO cells. Molecular Pharmacology. 2011; August 19^th: available online.

Schramm A, Baburin I, Hering S, Hamburger M. HERG channel inhibitors in extracts of coptidis rhizoma. Planta Medica. 2011;77(7):692-697.

Taboureau O, Jørgensen FS. In silico Predictions of hERG Channel Blockers in Drug Discovery: From Ligand-Based and Target-Based Approaches to Systems Chemical Biology. Comb Chem High Throughput Screen. 2011;14(5):375-87.

Marchese Robinson RL, Glen RC, Mitchell JBO. Development and Comparison of hERG Blocker Classifiers: Assessment on Different Datasets Yields Markedly Different Results Molecular Informatics. 2011;30(5):443-458.

Obiol-Pardo C, Gomis-Tena J, Sanz F, Saiz J, Pastor M. A Multiscale Simulation System for the Prediction of Drug-Induced Cardiotoxicity. Journal of Chemical Information and Modeling. 2011;51(2):483-492.

Beyer BK, Chernoff N, Danielsson BR, et al. ILSI/HESI maternal toxicity workshop summary: maternal toxicity and its impact on study design and data interpretation. Birth Defects Research Part B - Developmental and Reproductive Toxicology. 2011;92(1):36-51.

Schmalhofer WA, Swensen AM, Thomas BS, et al. A Pharmacologically Validated, High-Capacity, Functional Thallium Flux Assay for the Human Ether-á-go-go Related Gene Potassium Channel. Assay and Drug Development Technologies. 2010;8(6):714-726

Huang XP, Mangano T, Hufeisen S, Setola V, Roth BL. Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting. Assay and Drug Development Technologies. 2010;8(6):727-42.

Sprous D.G., Palmer R.K., Swanson J.T., Lawless M. QSAR in the pharmaceutical research setting: QSAR models for broad, large problems. Curr. Top. Med. Chem. Current Topics in Medicinal Chemistry. 2010;10(6):619-637.

Sprous D, Palmer K. The T1R2/T1R3 Sweet Receptor and TRPM5 Ion Channel: Taste Targets with Therapeutic Potential. Progress in Molecular Biology and Translational Science. 2010;91:151-208.

Raschi E., De Ponti F., Ceccarini L., Recanatini M. HERG-related drug toxicity and models for predicting hERG liability and QT prolongation. Expert Opinion on Drug Metabolism and Toxicology. 2009;5(9):1005-1021.