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update

02-07-2012


Version 1.2

New stable version has been published. It contains brand new as well as significant upgrades of the existing features. All of them are listed below and in the manual.

- hERG genetic variability simulation and analysis (built-in and user-defined mutations/polymorphisms)

- built-in functional description of the most commonly found polymorphic variant (K897T)

- NEurCaucasian population description regarding the polymorphic variants

update

18-12-2011


Version 1.1

New stable version has been published. It contains brand new as well as significant upgrades of the existing features. All of them are listed below and in the manual.

- new element in menu and new usability - panel 'drug physiology' allows to include the drugs triggered positive and negative modification of the physiological parameters namely plasma ionic concentrations (K+, Na+, Ca2+) and heart rate (stimulation period); drugs causing such effects are i.e. beta-2-adrenomimetics which do not significantly modify ionic currents (low plasma concentration) but their usage can be connected with the increase risk of heart arrhythmia (heart rate elevation by adrenergic stimulation and plasma potassium level decrease)

- panel 'cardiomyocytes' contains new features which allow to define the population variability of left ventricular heart wall thickness; it can be done either in non-physiological (CV) or physiological mode; the latter one comes from the Sjögren model defining sex-age-LVW thickness correlation

- population variability in the heart rate can be now incorporated in the 'settings' panel where the default CV value (equal to 0) can be changed to any other number; it is a first step announcing totally new feature which will be incorporated in version 2.0 - model describing sex related circadian rhythm of the heart rate

- results file comes with the detailed analysis of the psedudoECG outputted by the system; it contains QT/QTc (Fridericia correction - Ref 1 and Ref 2) interval analysis individually for all patients included into the virtual clinical trial

update

16-11-2011


Version 1.0 Build 326

- small graphical changes to the layout

- small bugs fixed - step size and decimal precision in the reports

update

10-11-2011


Version 1.0 Build 309

- additional features added to the output report - detailed Action Potential (AP) description

update

09-11-2011


Version 1.0

List of the new features in version 1.0:
- 1D pseudoECG simulation and reporting

- automatic analysis of the APD50 and APD90

- IKs current inhibition prediction based on the extendedQSAR model

- flexible simulation and output settings

- sdf/mol files upload and automatic descriptors calculation for further utilization (IKr and IKs currents inhibition)

It is out great pleasure to announce the cooperation with Chemaxon leading cheminformatic solutions provider. All calculators work based on the delivered technologies!